Inhibition of pancreatic secretion in man by cigarette smoking

Cigarette smoking has been linked to an elevated incidence of duodenal ulcer disease in smokers, although the mechanism is unclear. In 23 young normal subjects single or double secretin tests were performed during non-smoking and smoking periods. Cigarette smoking inhibited the secretion of pancreat...

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Bibliographic Details
Published in:Gut 1972-05, Vol.13 (5), p.361-365
Main Authors: Bynum, T. E., Solomon, Travis E., Johnson, Leonard R., Jacobson, Eugene D.
Format: Article
Language:English
Subjects:
Adult
Bicarbonates - metabolism
Duodenal Ulcer - etiology
Humans
Male
Pancreas - metabolism
Pancreatic Juice - metabolism
Secretin
Smoking - complications
Smoking - physiopathology
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Summary:Cigarette smoking has been linked to an elevated incidence of duodenal ulcer disease in smokers, although the mechanism is unclear. In 23 young normal subjects single or double secretin tests were performed during non-smoking and smoking periods. Cigarette smoking inhibited the secretion of pancreatic juice and bicarbonate in light smokers (< one pack/day for < three years). Heavy smokers (> one pack/day for > three years) exhibited depressed pancreatic secretory rates during non-smoking periods. Inhibition of pancreatic alkaline secretion by cigarette smoking could be the link between the habit and duodenal ulcer disease.
ISSN:0017-5749
1468-3288
1458-3288
DOI:10.1136/gut.13.5.361