HLA and cell-mediated immunity in HBsAg negative chronic active hepatitis

In 20 patients with severe HBsAg negative chronic active hepatitis a significant association has been found between the HLA determinants A1, B8, and Dw3 and cell-mediated immunity directed against human liver specific lipoprotein in vitro. This observation induces further speculation that genetic im...

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Bibliographic Details
Published in:Gut 1979-06, Vol.20 (6), p.523-525
Main Authors: Vogten, A J, Shorter, R G, Opelz, G
Format: Article
Language:English
Subjects:
Adult
Chronic Disease
Epitopes
Female
Hepatitis - immunology
Hepatitis B Surface Antigens
HLA Antigens - immunology
Humans
Immunity, Cellular
Male
Middle Aged
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Summary:In 20 patients with severe HBsAg negative chronic active hepatitis a significant association has been found between the HLA determinants A1, B8, and Dw3 and cell-mediated immunity directed against human liver specific lipoprotein in vitro. This observation induces further speculation that genetic immunoregulatory action might be involved in the pathogenetic mechanisms of chronic active hepatitis in vivo.
ISSN:0017-5749
1468-3288
1458-3288
DOI:10.1136/gut.20.6.523