Studies on the stability of vitamin A in the stomach and small intestine

The instability of vitamin A alcohol relative to vitamin A acetate has been studied in vivo and in vitro. Vitamin A alcohol is more unstable than vitamin A acetate in human gastric and duodenal juice and in rats' stomachs and intestines and is more marked at lower pH levels and in rats' st...

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Bibliographic Details
Published in:Gut 1962-09, Vol.3 (3), p.264-266
Main Authors: Fitzgerald, Oliver, Fennelly, James J., Hingerty, Daniel J.
Format: Article
Language:English
Subjects:
Animals
Gastric Juice
Humans
Intestine, Small
Intestines
Male
Old Medline
Rats
Stomach
Vitamin A
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Summary:The instability of vitamin A alcohol relative to vitamin A acetate has been studied in vivo and in vitro. Vitamin A alcohol is more unstable than vitamin A acetate in human gastric and duodenal juice and in rats' stomachs and intestines and is more marked at lower pH levels and in rats' stomachs. Alpha tocopherol improved the absorption curve of vitamin A alcohol in man by protecting it in gastric and duodenal juice. This protective effect could not be demonstrated in the rat.
ISSN:0017-5749
1468-3288
1458-3288
DOI:10.1136/gut.3.3.264