Natural progesterone and antihypertensive action

In a placebo controlled, double blind crossover study natural progesterone was given by mouth, in increasing doses, to six men and four postmenopausal women with mild to moderate hypertension who were not receiving any other antihypertensive drugs. When compared with values recorded before treatment...

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Bibliographic Details
Published in:BMJ 1985-01, Vol.290 (6461), p.13-14
Main Authors: Rylance, P B, Brincat, M, Lafferty, K, De Trafford, J C, Brincat, S, Parsons, V, Studd, J W
Format: Article
Language:English
Subjects:
Adult
Aged
Antihypertensives
Blood
Blood pressure
Clinical Research
Clinical Trials as Topic
Dosage
Double-Blind Method
Female
Gynecology
Humans
Hypertension
Hypertension - drug therapy
Male
Men
Menopause
Middle Aged
Oral contraceptives
Placebos
Postmenopause
Posture
Progesterone - therapeutic use
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Summary:In a placebo controlled, double blind crossover study natural progesterone was given by mouth, in increasing doses, to six men and four postmenopausal women with mild to moderate hypertension who were not receiving any other antihypertensive drugs. When compared with values recorded before treatment and during administration of placebo progesterone caused a significant reduction in blood pressure, suggesting that progesterone has an antihypertensive action rather than a hypertensive one as has been previously thought. This possible protective effect of progesterone should be investigated further.
ISSN:0267-0623
0959-8138
1468-5833
DOI:10.1136/bmj.290.6461.13