Effects of bombesin on gastrin and gastric acid secretion in patients with duodenal ulcer

The effect of bombesin, a possible neurotransmitter of gastrin release, upon gastrin and gastric acid secretion was investigated in 25 patients with duodenal ulcer and in 16 normal subjects. In patients with duodenal ulcer bombesin (10 ng/kg/min) produced an increase in plasma gastrin output (median...

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Bibliographic Details
Published in:Gut 1983-03, Vol.24 (3), p.231-235
Main Authors: Fave, G Delle, Kohn, Anna, De Magistris, Laura, Annibale, B, Bruzzone, R, Sparvoli, C, Severi, Carola, Torsoli, A
Format: Article
Language:English
Subjects:
Adult
Bombesin - pharmacology
Dietary Proteins - pharmacology
Duodenal Ulcer - metabolism
Female
Gastric Acid - metabolism
Gastric Mucosa - drug effects
Gastric Mucosa - metabolism
Gastrins - metabolism
Humans
Male
Middle Aged
Pentagastrin - pharmacology
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Summary:The effect of bombesin, a possible neurotransmitter of gastrin release, upon gastrin and gastric acid secretion was investigated in 25 patients with duodenal ulcer and in 16 normal subjects. In patients with duodenal ulcer bombesin (10 ng/kg/min) produced an increase in plasma gastrin output (median 22·4 (range 7·5-75·8) pmol/l/min) similar to that obtained in normal subjects (median 24·4 (range 5·8-56·5) pmol/l/min), whereas gastrin stimulated by a meal was significantly higher in the group of patients with duodenal ulcer (median 20·7 (range 9·2-42·9) vs 16·2 (range 3·4-22·2) p
ISSN:0017-5749
1468-3288
1458-3288
DOI:10.1136/gut.24.3.231