HLA antigens and atopy in children with coeliac disease

HLA antigens and various aspects of atopy were studied in 42 Finnish children and adolescents with coeliac disease, and the results were compared with findings of recent population studies. The HLA associations were as expected: relative risks for coeliac disease in individuals with HLA-B8, DR3, and...

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Bibliographic Details
Published in:Gut 1983-04, Vol.24 (4), p.306-310
Main Authors: Verkasalo, M, Tiilikainen, A, Kuitunen, P, Savilahti, E, Backman, A
Format: Article
Language:English
Subjects:
Adolescent
Celiac Disease - immunology
Child
Child, Preschool
Female
Histocompatibility Antigens Class II - immunology
HLA Antigens - immunology
HLA-B8 Antigen
HLA-DR3 Antigen
HLA-DR7 Antigen
Humans
Hypersensitivity, Immediate - immunology
Male
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Summary:HLA antigens and various aspects of atopy were studied in 42 Finnish children and adolescents with coeliac disease, and the results were compared with findings of recent population studies. The HLA associations were as expected: relative risks for coeliac disease in individuals with HLA-B8, DR3, and DR7 were 8 . 0, 18 . 6, and 15 . 0, respectively. Children with coeliac disease were significantly more often atopic than unselected schoolchildren. Atopy was significantly more frequent and the onset of coeliac disease later for B8/DR3- patients than B8/DR3+ patients. There was no obvious relation between DR7 and atopy. It is concluded that atopy predisposes to coeliac disease partly independently of the HLA-DR3 associated disease susceptibility gene(s), and that different mechanisms may operate in the pathogenesis in coeliac disease patients with and without atopy.
ISSN:0017-5749
1468-3288
1458-3288
DOI:10.1136/gut.24.4.306