Gastrointestinal carcinoids: characterization by site of origin and hormone production

To describe a large series of patients with carcinoid tumors in terms of presenting symptoms, hormonal data, stage at diagnosis, pathologic features, and survival. Published series have described significant prognostic features of carcinoid tumors as site of origin, age, sex, stage at diagnosis, pre...

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Bibliographic Details
Published in:Annals of surgery 2000-10, Vol.232 (4), p.549-556
Main Authors: Onaitis, M W, Kirshbom, P M, Hayward, T Z, Quayle, F J, Feldman, J M, Seigler, H F, Tyler, D S
Format: Article
Language:English
Subjects:
Carcinoid Tumor - diagnosis
Carcinoid Tumor - metabolism
Carcinoid Tumor - mortality
Databases, Factual
Female
Gastrointestinal Neoplasms - diagnosis
Gastrointestinal Neoplasms - metabolism
Gastrointestinal Neoplasms - mortality
Hormones, Ectopic - metabolism
Humans
Hydroxyindoleacetic Acid - urine
Male
Malignant Carcinoid Syndrome - epidemiology
Middle Aged
Neoplasm Staging
Pancreatic Neoplasms - diagnosis
Pancreatic Neoplasms - metabolism
Pancreatic Neoplasms - mortality
Predictive Value of Tests
Prognosis
Retrospective Studies
Scientific Papers
Serotonin - metabolism
Survival Analysis
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Summary:To describe a large series of patients with carcinoid tumors in terms of presenting symptoms, hormonal data, stage at diagnosis, pathologic features, and survival. Published series have described significant prognostic features of carcinoid tumors as site of origin, age, sex, stage at diagnosis, presence of high hormone levels, and increased T stage. Of these, stage at diagnosis and T stage seem to emerge most often as independent predictors of survival in multivariate analyses. Of carcinoid tumors, those arising from a midgut location have higher levels of serotonin and serotonin breakdown products, as well as more frequent metastatic disease at presentation, than those arising from either foregut or hindgut locations. A prospective database of carcinoid patients seen at Duke University Medical Center was kept from 1970 to the present. Retrospective medical record review was performed on this database to record presenting symptoms, hormonal data, pathologic features, and survival. Statistical methods included analysis of variance, Kaplan-Meier analysis, and Mantel-Cox proportional hazard survival analysis, with P
ISSN:0003-4932
1528-1140
DOI:10.1097/00000658-200010000-00010