Effects of single and repeated doses of omeprazole on gastric acid and pepsin secretion in man

The effects of omeprazole, a substituted benzimidazole, on gastric acid and pepsin secretion have been studied in twelve healthy subjects. From six to eight hours after a single oral dose of 30 mg, there was a 66% reduction in basal acid output, and a 71.2% reduction in pentagastrin stimulated acid...

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Bibliographic Details
Published in:Gut 1984-07, Vol.25 (7), p.707-710
Main Authors: Howden, C W, Forrest, J A, Reid, J L
Format: Article
Language:English
Subjects:
Adult
Anti-Ulcer Agents - pharmacology
Benzimidazoles - pharmacology
Biological and medical sciences
Digestive system
Dose-Response Relationship, Drug
Gastric Acid - metabolism
Humans
Male
Medical sciences
Omeprazole
Pentagastrin - pharmacology
Pepsin A - metabolism
Pharmacology. Drug treatments
Secretory Rate - drug effects
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Summary:The effects of omeprazole, a substituted benzimidazole, on gastric acid and pepsin secretion have been studied in twelve healthy subjects. From six to eight hours after a single oral dose of 30 mg, there was a 66% reduction in basal acid output, and a 71.2% reduction in pentagastrin stimulated acid output. A single dose of 60 mg produced a 91.7% reduction in basal acid output and a 95.3% reduction in pentagastrin stimulated acid output. After seven days treatment with 30 or 60 mg daily, there was almost 100% inhibition of both basal and pentagastrin stimulated acid output. Omeprazole did not significantly affect pepsin secretion which is in keeping with its proposed mode of action, as an inhibitor of the H+/K+-ATPase enzyme on the secretory membrane of the parietal cell. There were no side effects after omeprazole either with single or repeated dosing.
ISSN:0017-5749
1468-3288
1458-3288
DOI:10.1136/gut.25.7.707