Subnormal activation of phagocytes by complement in chronic inflammatory bowel disease? Neutrophil chemotaxis to complement split product C5a

The capacity of circulating phagocytes for activation by complement was investigated in consecutive, untreated cases of chronic inflammatory bowel disease. The major complement derived chemotactic factor, C5a, served as chemoattractant in dose response studies of neutrophil chemotaxis. A similar, si...

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Bibliographic Details
Published in:Gut 1984-07, Vol.25 (7), p.737-742
Main Author: Elmgreen, J
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Caseins - immunology
Chemotaxis, Leukocyte
Colitis, Ulcerative - immunology
Complement C5 - immunology
Complement C5a
Crohn Disease - immunology
Dose-Response Relationship, Immunologic
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Male
Medical sciences
Middle Aged
Neutrophils - immunology
Other diseases. Semiology
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
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Summary:The capacity of circulating phagocytes for activation by complement was investigated in consecutive, untreated cases of chronic inflammatory bowel disease. The major complement derived chemotactic factor, C5a, served as chemoattractant in dose response studies of neutrophil chemotaxis. A similar, significantly decreased sensitivity and peak response was revealed in patients with Crohn's disease and ulcerative colitis. This subnormal function of neutrophils could be shown even in cases of complete clinical remission. Chemotactic response to casein and spontaneous motility was within the normal range showing an unaffected basic cell function of neutrophils in the patients. The study shows a dysfunction of phagocytic cells, related to potentially important phlogistic mediators, in chronic inflammatory bowel disease.
ISSN:0017-5749
1468-3288
1458-3288
DOI:10.1136/gut.25.7.737