Gastric acid secretion and gastrin production in the short bowel syndrome

Excess gastric acid secretion and gastrin production may occur in patients with the short bowel syndrome but the two measurements have never been made simultaneously in man in response to a food stimulus. Using the technique of intragastric titration, this was carried out in eight patients after ext...

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Bibliographic Details
Published in:Gut 1985-09, Vol.26 (9), p.914-919
Main Authors: Williams, N S, Evans, P, King, R F
Format: Article
Language:English
Subjects:
Biological and medical sciences
Female
Gastric Acid - metabolism
Gastrins - biosynthesis
Gastrins - blood
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Malabsorption Syndromes - metabolism
Male
Medical sciences
Middle Aged
Other diseases. Semiology
Pentagastrin - pharmacology
Short Bowel Syndrome - blood
Short Bowel Syndrome - metabolism
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
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Summary:Excess gastric acid secretion and gastrin production may occur in patients with the short bowel syndrome but the two measurements have never been made simultaneously in man in response to a food stimulus. Using the technique of intragastric titration, this was carried out in eight patients after extensive small bowel resection resulting mainly from vascular occlusion and in eight matched normal control subjects. Basal acid output and peak acid output in response to pentagastrin was also measured separately. Although peak and integrated serum gastrin concentrations were significantly greater in patients (450 +/- SE 109 pg/ml; 113 +/- 2.9X10(-3) pg/ml/min) compared with control subjects (174 +/- 98 pg/ml; 6.1 +/- 2.0X10(-3) pg/ml/min p less than 0.05), no concomitant increase in acid secretion was shown either during intragastric titration or in response to pentagastrin. These findings indicate that there is no rationale for treating these patients with long term anti-ulcer therapy.
ISSN:0017-5749
1468-3288
1458-3288
DOI:10.1136/gut.26.9.914