Mycobacterial aetiology of Crohn's disease: serologic study using common mycobacterial antigens and a species-specific glycolipid antigen from Mycobacterium paratuberculosis

Crohn's disease is a granulomatous form of enteritis superficially similar to Johne's disease (paratuberculosis) of ruminants. Recently, a Mycobacterium sp closely related to Mycobacterium paratuberculosis was cultured from tissues of patients with Crohn's disease suggesting that M pa...

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Bibliographic Details
Published in:Gut 1986-11, Vol.27 (11), p.1353-1356
Main Authors: Cho, S N, Brennan, P J, Yoshimura, H H, Korelitz, B I, Graham, D Y
Format: Article
Language:English
Subjects:
Antibody Formation
Antigens, Bacterial - immunology
Biological and medical sciences
Crohn Disease - etiology
Crohn Disease - immunology
Crohn Disease - microbiology
Enzyme-Linked Immunosorbent Assay
Gastroenterology. Liver. Pancreas. Abdomen
Glycolipids - immunology
Humans
Medical sciences
Mycobacterium - immunology
Mycobacterium Infections - complications
Mycobacterium Infections - immunology
Other diseases. Semiology
Paratuberculosis - microbiology
Species Specificity
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
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Summary:Crohn's disease is a granulomatous form of enteritis superficially similar to Johne's disease (paratuberculosis) of ruminants. Recently, a Mycobacterium sp closely related to Mycobacterium paratuberculosis was cultured from tissues of patients with Crohn's disease suggesting that M paratuberculosis may be the aetiologic agent in some cases. In addition, greater seroreactivity to M paratuberculosis has been reported in patients with Crohn's disease. In the present study, we have evaluated the serum antibody response to disrupted M paratuberculosis using ELISA and serum specimens from 33 people with Crohn's disease, 21 with ulcerative colitis, and 12 non-inflammatory bowel disease controls. We failed to find a consistent IgG, IgM, or IgA antibody response to Mycobacterium paratuberculosis. The results indicate that, as in bovine paratuberculosis, serum seroreactivity is not a reliable tool for examining the relationship between human intestinal disease and mycobacteria.
ISSN:0017-5749
1468-3288
1458-3288
DOI:10.1136/gut.27.11.1353