Effect of dietary fat on the small intestinal mucosa

The presence of food within the small intestinal lumen promotes mucosal cell proliferation. To define the trophic role of triglycerides, three groups of eight female Wistar rats were isocalorically fed for four weeks with either Vivonex, or Vivonex with 50% calorie substitution with an essential fat...

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Bibliographic Details
Published in:Gut 1989-09, Vol.30 (9), p.1252-1255
Main Authors: Maxton, D G, Cynk, E U, Jenkins, A P, Thompson, R P
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Dietary Fats - pharmacology
Dietary Fats, Unsaturated - pharmacology
DNA - analysis
Fatty Acids, Essential - pharmacology
Female
Food Additives - pharmacology
Fundamental and applied biological sciences. Psychology
Intestinal Mucosa - analysis
Intestinal Mucosa - anatomy & histology
Intestinal Mucosa - drug effects
Intestine, Small - analysis
Intestine, Small - anatomy & histology
Intestine, Small - drug effects
Intestine. Mesentery
Organ Size
Organic Chemicals
Rats
Rats, Inbred Strains
Vertebrates: digestive system
Weight Gain
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Summary:The presence of food within the small intestinal lumen promotes mucosal cell proliferation. To define the trophic role of triglycerides, three groups of eight female Wistar rats were isocalorically fed for four weeks with either Vivonex, or Vivonex with 50% calorie substitution with an essential fatty acid mixture, or Vivonex with 50% calorie substitution with a saturated fatty acid mixture. Although Vivonex caused greater body weight gain, both essential fatty acids and saturated fatty acids increased small intestinal weight, mucosal weight, protein and DNA overall, and in each of three intestinal segments (proximal, middle and distal), compared with Vivonex. Mucosal indices were similar for essential fatty acids and saturated fatty acids. These results show that triglycerides, regardless of essential fatty acid content, are trophic to the rat small intestinal mucosa.
ISSN:0017-5749
1468-3288
1458-3288
DOI:10.1136/gut.30.9.1252