Significance of venous and lymphatic invasion in malignant polyps of the colon and rectum

Three hundred and sixty seven neoplastic colorectal polyps removed at endoscopy of which 34 were complicated by invasive carcinoma, were reviewed clinically and histologically to assess the prevalence and clinical significance of venous and or lymphatic invasion. Traditional stains for histological...

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Bibliographic Details
Published in:Gut 1989-10, Vol.30 (10), p.1385-1391
Main Authors: Muller, S, Chesner, I M, Egan, M J, Rowlands, D C, Collard, M J, Swarbrick, E T, Newman, J
Format: Article
Language:English
Subjects:
Biological and medical sciences
Colon - blood supply
Colonic Polyps - pathology
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Intestinal Polyps - pathology
Lymphatic Metastasis
Medical sciences
Neoplasm Invasiveness
Rectal Neoplasms - pathology
Rectum - blood supply
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
Veins - pathology
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Summary:Three hundred and sixty seven neoplastic colorectal polyps removed at endoscopy of which 34 were complicated by invasive carcinoma, were reviewed clinically and histologically to assess the prevalence and clinical significance of venous and or lymphatic invasion. Traditional stains for histological assessment were supplemented by immunohistochemical methods. Venous and or lymphatic invasion was present in six cases (17.6%), with a statistically significant association with recurrent carcinoma or Dukes's C carcinoma in polyps otherwise regarded as completely excised. The presence or absence of venous and or lymphatic invasion in malignant polyps should be documented as if present, further treatment is indicated. A combination of haematoxylin and eosin and elastic-van Gieson stains will usually identify the presence of vascular invasion. Where a discrepancy arises, however, additional immunohistochemical stains may be of value.
ISSN:0017-5749
1468-3288
1458-3288
DOI:10.1136/gut.30.10.1385