New approach to the localisation of phaeochromocytoma: imaging with iodine-131-meta-iodobenzylguanidine

Thirty eight patients with known or suspected phaeochromocytoma were studied by radioisotope imaging after intravenous administration of iodine-131-meta- iodobenzylguanidine (131I- mIBG ), a radiopharmaceutical which has affinity for chromaffin tumours. Seventeen positive results (including one fals...

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Bibliographic Details
Published in:BMJ 1984-05, Vol.288 (6430), p.1587-1591
Main Authors: Ackery, D M, Tippett, P A, Condon, B R, Sutton, H E, Wyeth, P
Format: Article
Language:English
Subjects:
3-Iodobenzylguanidine
Abdomen
Adolescent
Adrenal Gland Neoplasms - diagnostic imaging
Adrenal Gland Neoplasms - urine
Adult
Aged
Biochemistry
Catecholamines
Computerized axial tomography
Dopamine - urine
Epinephrine - urine
Excretion
False negative errors
Female
Hospital Topics
Humans
Imaging
Iodine Radioisotopes
Iodobenzenes
Male
Middle Aged
Neoplasia
Norepinephrine
Norepinephrine - urine
Pheochromocytoma - diagnostic imaging
Pheochromocytoma - secondary
Pheochromocytoma - urine
Radionuclide Imaging
Skeleton
Tissue Distribution
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Description
Summary:Thirty eight patients with known or suspected phaeochromocytoma were studied by radioisotope imaging after intravenous administration of iodine-131-meta- iodobenzylguanidine (131I- mIBG ), a radiopharmaceutical which has affinity for chromaffin tumours. Seventeen positive results (including one false positive) and 21 negative results (including two false negatives) were obtained. Clinical accuracy was 92%. Urinary noradrenaline concentrations were raised in all patients with confirmed phaeochromocytoma. These findings show that 131I- mIBG is of value in localising and assessing the extent of chromaffin tumours.
ISSN:0007-1447
0267-0623
0959-8138
1468-5833
DOI:10.1136/bmj.288.6430.1587