Body content of selenium in coeliac disease

Concentrations of selenium in whole blood, plasma, and leucocytes were determined in 16 patients with coeliac disease confirmed by biopsy and 32 controls. All the patients were clinically well and receiving gluten free diets. The concentrations of selenium were significantly lower in the leucocytes,...

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Bibliographic Details
Published in:BMJ 1984-06, Vol.288 (6434), p.1862-1863
Main Authors: Hinks, L J, Inwards, K D, Lloyd, B, Clayton, B E
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Blood
Blood plasma
Body Composition
Celiac Disease - blood
Chronic diseases
Clinical Research
Digestive system diseases
Epidemiology
Female
Gastroenterology. Liver. Pancreas. Abdomen
Gluten free diets
Humans
Leukocytes
Leukocytes - analysis
Male
Medical sciences
Middle Aged
Other diseases. Semiology
Plasma - analysis
Selenium
Selenium - blood
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
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Summary:Concentrations of selenium in whole blood, plasma, and leucocytes were determined in 16 patients with coeliac disease confirmed by biopsy and 32 controls. All the patients were clinically well and receiving gluten free diets. The concentrations of selenium were significantly lower in the leucocytes, blood, and plasma of patients compared with controls, probably indicating a decrease in the body content of selenium. A high incidence of malignancy in coeliac disease has been reported. As a protective role for selenium against cancer has been postulated, the importance of this unexpected observation of lowered tissue concentrations of selenium requires further investigation.
ISSN:0007-1447
0267-0623
0959-8138
1468-5833
DOI:10.1136/bmj.288.6434.1862