Use of a long acting somatostatin analogue in controlling life threatening ileostomy diarrhoea

A woman presented with persistent ileostomy diarrhoea unresponsive to conventional drug treatment and necessitating parenteral nutrition. Output was four to six litres of watery fluid per 24 hours while she was receiving oral nutrition and two to three litres when she was starved. Treatment with a l...

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Bibliographic Details
Published in:BMJ 1984-10, Vol.289 (6451), p.1027-1028
Main Authors: Williams, N S, Cooper, J C, Axon, A T, King, R F, Barker, M
Format: Article
Language:English
Subjects:
Biological and medical sciences
Clinical Research
Diarrhea
Diarrhea - drug therapy
Diarrhea - metabolism
Diet
Digestive system
Electrolytes
Female
Fistulas
Gastric emptying
Humans
Ileostomy
Ileum
Medical sciences
Middle Aged
Octreotide
Pharmacology. Drug treatments
Placebos
Postoperative Complications
Potassium
Small intestine
Somatostatin - analogs & derivatives
Somatostatin - therapeutic use
Time Factors
Water-Electrolyte Balance
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Summary:A woman presented with persistent ileostomy diarrhoea unresponsive to conventional drug treatment and necessitating parenteral nutrition. Output was four to six litres of watery fluid per 24 hours while she was receiving oral nutrition and two to three litres when she was starved. Treatment with a long acting analogue of somatostatin (50 micrograms subcutaneously every 12 hours) reduced the ileostomy output to 2.0-2.5 litres/24 hours with an oral diet and the effluent became semiformed. Parenteral fluids could be stopped. Somatostatin may have a role in the treatment of secretory diarrhoea, but prospective controlled trials are necessary.
ISSN:0007-1447
0267-0623
0959-8138
1468-5833
DOI:10.1136/bmj.289.6451.1027