Diabetic hypertriglyceridaemia and related 5' flanking polymorphism of the human insulin gene

A polymorphic DNA sequence was studied on the 5' flanking region of the human insulin gene in relation to diabetic lipaemia. The genotype frequencies in a control population (n = 52) were homozygous L 6%, heterozygous 54%, and homozygous S 40%. Corresponding genotype frequencies in a hypertrigl...

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Bibliographic Details
Published in:BMJ 1984-01, Vol.288 (6411), p.96-99
Main Authors: Jowett, N I, Williams, L G, Hitman, G A, Galton, D J
Format: Article
Language:English
Subjects:
Adult
Aged
Alleles
Autoradiography
Biological and medical sciences
Clinical Research
Diabetes
Diabetes complications
Diabetes mellitus
Diabetes Mellitus - genetics
Diabetes. Impaired glucose tolerance
DNA
DNA - genetics
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Female
Genes
Genetic loci
Genotype
Genotypes
Humans
Hybridization, Genetic
Hyperlipoproteinemias - complications
Hyperlipoproteinemias - genetics
Insulin
Insulin - genetics
Male
Medical sciences
Middle Aged
Polymorphism, Genetic
Type 1 diabetes mellitus
Type 2 diabetes mellitus
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Summary:A polymorphic DNA sequence was studied on the 5' flanking region of the human insulin gene in relation to diabetic lipaemia. The genotype frequencies in a control population (n = 52) were homozygous L 6%, heterozygous 54%, and homozygous S 40%. Corresponding genotype frequencies in a hypertriglyceridaemic group (n = 74) were 18%, 66%, and 16% (p less than 0.01; chi 2 test). When the hypertriglyceridaemic patients were divided on the basis of glucose tolerance the corresponding genotype frequencies in the diabetic subgroup (n = 23) were 39%, 52%, and 9% compared with 0%, 74%, and 26% in the non-diabetics (n = 34) (p less than 0.001; chi 2 test). These findings suggest that the homozygous L genotype may confer susceptibility to diabetic hypertriglyceridaemia.
ISSN:0007-1447
0267-0623
0959-8138
1468-5833
DOI:10.1136/bmj.288.6411.96