Tardive dyskinesia associated with metoclopramide

Eleven cases of tardive dyskinesia associated with metoclopramide have been reported to the Swedish Adverse Drug Reactions Advisory Committee from 1977 to 1981, 10 of which developed during the past three years. All patients were women, with a mean age of 76 years. Median duration of treatment befor...

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Bibliographic Details
Published in:BMJ 1984-02, Vol.288 (6416), p.545-547
Main Authors: Wiholm, B E, Mortimer, O, Boethius, G, Häggström, J E
Format: Article
Language:English
Subjects:
Adverse drug reactions
Age Factors
Aged
Biological and medical sciences
Clinical Topics
Corporations
Dosage
Drug Administration Schedule
Drug prescriptions
Drug toxicity and drugs side effects treatment
Drug withdrawal symptoms
Dyskinesia, Drug-Induced - epidemiology
Dyskinesia, Drug-Induced - etiology
Female
Humans
Medical sciences
Metoclopramide - administration & dosage
Metoclopramide - adverse effects
Older adults
Parkinsonian disorders
Pharmacies
Pharmacology. Drug treatments
Prescription drugs
Sex Factors
Sweden
Tardive dyskinesia
Toxicity: nervous system and muscle
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Summary:Eleven cases of tardive dyskinesia associated with metoclopramide have been reported to the Swedish Adverse Drug Reactions Advisory Committee from 1977 to 1981, 10 of which developed during the past three years. All patients were women, with a mean age of 76 years. Median duration of treatment before the onset of symptoms was 14 months. Calculated from total drug sales and prescription statistics the incidence of tardive dyskinesia during treatment with metoclopramide was estimated to be one in 2000-2800 treatment years. Extrapolation of data on long term treatment (more than six months) of patients aged 70 years or more, from a survey based on individual prescriptions yielded an incidence of more than one in a 1000 patients. Long term treatment with metoclopramide is accompanied by a substantial risk of developing tardive dyskinesia especially among elderly people.
ISSN:0007-1447
0267-0623
0959-8138
1468-5833
DOI:10.1136/bmj.288.6416.545