Accuracy of physical examination, ultrasonography, and mammography in predicting residual pathologic tumor size in patients treated with neoadjuvant chemotherapy

• Published in: Annals of surgery 2006-02, Vol.243 (2), p.257-264
• Main Authors: CHAGPAR, Anees B, MIDDLETON, Lavinia P, KUERER, Henry M, MERIC-BERNSTAM, Funda, ROSS, Merrick I, SINGLETARY, S. Eva, SAHIN, Aysegul A, DEMPSEY, Peter, BUZDAR, Aman U, MIRZA, Attiqa N, AMES, Fredrick C, BABIERA, Gildy V, FEIG, Barry W, HUNT, Kelly K
• Format: Article
• Language: English
• Subjects: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biological and medical sciences; Breast Neoplasms - diagnostic imaging; Breast Neoplasms - drug therapy; Breast Neoplasms - pathology; Chemotherapy, Adjuvant; Cyclophosphamide - administration & dosage; Doxorubicin - administration & dosage; Female; Fluorouracil - administration & dosage; General aspects; Genital system. Mammary gland; Humans; Investigative techniques, diagnostic techniques (general aspects); Mammography; Medical sciences; Middle Aged; Neoadjuvant Therapy; Neoplasm Staging - methods; Neoplasm, Residual - diagnostic imaging; Neoplasm, Residual - drug therapy; Neoplasm, Residual - pathology; Original; Paclitaxel - administration & dosage; Physical Examination; Predictive Value of Tests; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Retrospective Studies; Statistics, Nonparametric; Ultrasonography, Mammary
• ISSN: 0003-4932; 1528-1140
• DOI: 10.1097/01.sla.0000197714.14318.6f

To assess the accuracy of physical examination, ultrasonography, and mammography in predicting residual size of breast tumors following neoadjuvant chemotherapy. Neoadjuvant chemotherapy is an accepted part of the management of stage II and III breast cancer. Accurate prediction of residual pathologic tumor size after neoadjuvant chemotherapy is critical in guiding surgical therapy. Although physical examination, ultrasonography, and mammography have all been used to predict residual tumor size, there have been conflicting reports about the accuracy of these methods in the neoadjuvant setting. We reviewed the records of 189 patients who participated in 1 of 2 protocols using doxorubicin-containing neoadjuvant chemotherapy, and who had assessment by physical examination, ultrasonography, and/or mammography no more than 60 days before their surgical resection. Size correlations were performed using Spearman rho analysis. Clinical and pathologic measurements were also compared categorically using the weighted kappa statistic. Size estimates by physical examination, ultrasonography, and mammography were only moderately correlated with residual pathologic tumor size after neoadjuvant chemotherapy (correlation coefficients: 0.42, 0.42, and 0.41, respectively), with an accuracy of +/-1 cm in 66% of patients by physical examination, 75% by ultrasonography, and 70% by mammography. Kappa values (0.24-0.35) indicated poor agreement between clinical and pathologic measurements. Physical examination, ultrasonography, and mammography were only moderately useful for predicting residual pathologic tumor size after neoadjuvant chemotherapy.