The Course of Malaria in Mice: Major Histocompatibility Complex (MHC) Effects, but No General MHC Heterozygote Advantage in Single-Strain Infections

A general MHC-heterozygote advantage in parasite-infected organisms is often assumed, although there is little experimental evidence for this. We tested the response of MHC-congenic mice (F2 segregants) to malaria and found the course of infection to be significantly influenced by MHC haplotype, par...

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Bibliographic Details
Published in:Genetics (Austin) 2005-07, Vol.170 (3), p.1427-1430
Main Authors: Wedekind, Claus, Walker, Mirjam, Little, Tom J
Format: Article
Language:English
Subjects:
Animals
Blood Cell Count
Body Weight
Crosses, Genetic
Disease Progression
Genotype & phenotype
Haplotypes - genetics
Heterozygote
Host-Parasite Interactions
Infections
Major Histocompatibility Complex - genetics
Malaria - genetics
Malaria - physiopathology
Mice
Mice, Inbred Strains
Parasitemia - parasitology
Parasites
Plasmodium chabaudi
Population
Sex Factors
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Summary:A general MHC-heterozygote advantage in parasite-infected organisms is often assumed, although there is little experimental evidence for this. We tested the response of MHC-congenic mice (F2 segregants) to malaria and found the course of infection to be significantly influenced by MHC haplotype, parasite strain, and host gender. However, the MHC heterozygotes did worse than expected from the average response of the homozygotes.
ISSN:0016-6731
1943-2631
1943-2631
DOI:10.1534/genetics.105.040683