Experimental studies of immunologically mediated enteropathy. III: Severe and progressive enteropathy during a graft-versus-host reaction in athymic mice

The graft-versus-host reaction (GvHR) in unirradiated (CBA X BALB/c)F1 mice normally produces a proliferative enteropathy consisting of crypt hyperplasia and increased numbers of intraepithelial lymphocytes (IEL), but villus atrophy does not occur. Host T lymphocytes can protect animals from the con...

Full description

Saved in:
Bibliographic Details
Published in:Immunology 1987-06, Vol.61 (2), p.185-188
Main Authors: MOWAT, A. M, FELSTEIN, M. V, BACA, M. E
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cytotoxicity, Immunologic
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Graft vs Host Reaction
Intestinal Diseases - immunology
Intestinal Diseases - pathology
Jejunum - immunology
Jejunum - pathology
Killer Cells, Natural - immunology
Male
Mice
Mice, Nude
Spleen - immunology
T-Lymphocytes, Cytotoxic - immunology
Tissue, organ and graft immunology
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The graft-versus-host reaction (GvHR) in unirradiated (CBA X BALB/c)F1 mice normally produces a proliferative enteropathy consisting of crypt hyperplasia and increased numbers of intraepithelial lymphocytes (IEL), but villus atrophy does not occur. Host T lymphocytes can protect animals from the consequences of a GvHR and, in this study, it is shown that athymic (CBA X BALB/c)F1 mice suffer a more severe systemic GvHR than intact hosts, with the unusual feature of specific anti-host cytotoxic T-lymphocyte (CTL) activity. In addition, nude mice not only had more intense crypt hyperplasia in the small intestine, but also had significant villus atrophy. It is concluded that host T cells normally prevent the progression of GvHR in unirradiated animals, and suggested that villus atrophy reflects a more severe form of the delayed-type hypersensitivity (DTH) reaction, the effects of which are normally limited to crypt hyperplasia.
ISSN:0019-2805
1365-2567