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A factor in the culture filtrate of some Klebsiella isolates specifically modifies the fibroblasts of HLA-B27-positive normal individuals

Cultured skin fibroblasts of HLA-B27-positive clinically normal individuals specifically bind, and are modified by, a factor in the culture filtrate of some Klebsiella isolates. These modified fibroblasts are serologically similar to the cells (lymphocytes and fibroblasts) of B27-positive patients w...

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Bibliographic Details
Published in:Immunology 1984-06, Vol.52 (2), p.385-387
Main Authors: RAYMENT, C, GECZY, A. F, BASHIR, H. V, EDMONDS, J. P
Format: Article
Language:English
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Summary:Cultured skin fibroblasts of HLA-B27-positive clinically normal individuals specifically bind, and are modified by, a factor in the culture filtrate of some Klebsiella isolates. These modified fibroblasts are serologically similar to the cells (lymphocytes and fibroblasts) of B27-positive patients with ankylosing spondylitis (B27+AS+). By contrast, B27+AS+ cells fail to bind the factor, presumably because a receptor present on B27+AS- cells has already been blocked or modified by a Klebsiella antigen in vivo.
ISSN:0019-2805
1365-2567