Genetic control of oral tolerance to ovalbumin in mice

We have investigated the genetic basis of oral tolerance to OVA in a number of inbred mouse strains. Our results emphasise the efficiency of the oral route for inducing tolerance and provide evidence for both MHC and non-MHC linked control of oral tolerance.

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Bibliographic Details
Published in:Immunology 1988-04, Vol.63 (4), p.737-739
Main Authors: LAMONT, A. G, MOWAT, A. M, BROWNING, M. J, PARROTT, D. M. V
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Antigens - administration & dosage
Biological and medical sciences
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Genes
Genetics of the immune response
Hypersensitivity, Delayed - immunology
Immune Tolerance
Immunobiology
Immunoglobulin G - biosynthesis
Major Histocompatibility Complex
Mice
Mice, Inbred Strains
Ovalbumin - immunology
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Description
Summary:We have investigated the genetic basis of oral tolerance to OVA in a number of inbred mouse strains. Our results emphasise the efficiency of the oral route for inducing tolerance and provide evidence for both MHC and non-MHC linked control of oral tolerance.
ISSN:0019-2805
1365-2567