Antibody formation by transferred cells in inbred fowls

Specific antibody formation by transferred cells from immunized donors has been demonstrated in adult recipients with cells derived from caecal tonsils, blood and peritoneal exudate as well as from spleen. Cells from all these sources formed both γM and γG antibody, regardless of whether the donors...

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Bibliographic Details
Published in:Immunology 1970-04, Vol.18 (4), p.473-482
Main Authors: Orlans, E, Rose, M E
Format: Article
Language:English
Subjects:
Animals
Antibody Formation
Antigens
Ascitic Fluid - cytology
Autoradiography
Cecum - cytology
Chickens
Humans
Immunization
Immunoglobulin G - biosynthesis
Immunoglobulin M - biosynthesis
Inbreeding
Lymphocytes - metabolism
Lymphoid Tissue - transplantation
Serum Albumin, Radio-Iodinated
Spleen - cytology
Transplantation, Homologous
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Summary:Specific antibody formation by transferred cells from immunized donors has been demonstrated in adult recipients with cells derived from caecal tonsils, blood and peritoneal exudate as well as from spleen. Cells from all these sources formed both γM and γG antibody, regardless of whether the donors had received one or two injections of antigen. There was no difference in the amount of antibody formed by cells from primary or secondary donors. An autoradiographic method for detecting small amounts of primary 7S fowl antibody (which does not give passive haemagglutination reactions) is described.
ISSN:0019-2805
1365-2567