Effect of pinealectomy on immune reactions in the rat

Non-inbred Wistar rats were pinealectomized at birth or in adult life, and tested for classical immune responses. Neonatal pinealectomy did not exert any notable effect on immune capacity of rats. On the other hand, rats pinealectomized at 6 weeks of age showed partial and transient impairment of im...

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Bibliographic Details
Published in:Immunology 1970-01, Vol.18 (1), p.1-6
Main Authors: Janković, B D, Isaković, K, Petrović, S
Format: Article
Language:English
Subjects:
Age Factors
Animals
Animals, Newborn
Antibody Formation
Arthus Reaction - immunology
Edema - pathology
Encephalomyelitis, Autoimmune, Experimental - immunology
Histocompatibility
Hypersensitivity, Delayed
Lymphoid Tissue - cytology
Pineal Gland - physiology
Rats
Serum Albumin, Bovine
Skin - pathology
Skin Transplantation
Transplantation Immunology
Transplantation, Homologous
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Summary:Non-inbred Wistar rats were pinealectomized at birth or in adult life, and tested for classical immune responses. Neonatal pinealectomy did not exert any notable effect on immune capacity of rats. On the other hand, rats pinealectomized at 6 weeks of age showed partial and transient impairment of immune potential. Arthus reactivity to bovine serum albumin was diminished and oedema of the skin less pronounced, and delayed reactions were reduced and of short duration. Slight delay in homograft rejection was noted. The incidence of allergic encephalomyelitis was diminished, and no clinical signs were observed. The cellular make-up of lymphoid tissues of pinealectomized adult rats was normal.
ISSN:0019-2805
1365-2567