Anti-thymocyte serum effects on Plasmodium berghei infection in rats

Rabbit anti-rat thymocyte serum (ATS) virtually abolished the innate resistance mechanism(s) of rats of different ages to primary infection with Plasmodium berghei . ATS apparently produced its immunosuppressant effect without arresting humoral antibody production as judged by agar-gel double diffus...

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Bibliographic Details
Published in:Immunology 1970-11, Vol.19 (5), p.759-766
Main Authors: Spira, D T, Silverman, P H, Gaines, C
Format: Article
Language:English
Subjects:
Age Factors
Animals
Antibody Formation
Female
Immune Sera
Immunity, Cellular
Immunodiffusion
Immunosuppressive Agents
Malaria - immunology
Rabbits
Rats
Reticulocytes
Thymus Gland - immunology
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Summary:Rabbit anti-rat thymocyte serum (ATS) virtually abolished the innate resistance mechanism(s) of rats of different ages to primary infection with Plasmodium berghei . ATS apparently produced its immunosuppressant effect without arresting humoral antibody production as judged by agar-gel double diffusion tests. These results, when considered together with those of other workers, suggest that cell-mediated immunity is substantially involved in resistance to P. berghei .
ISSN:0019-2805
1365-2567