Drosophila ATM and Mre11 are essential for the G2/M checkpoint induced by low-dose irradiation

Others have suggested recently that the conserved ATM checkpoint kinase is minimally involved in controlling the G(2)/M checkpoint in Drosophila that serves to prevent mitotic entry in the presence of DNA damage. Our data indicate that both ATM and its regulator Mre11 are important for the checkpoin...

Full description

Saved in:
Bibliographic Details
Published in:Genetics (Austin) 2005-10, Vol.171 (2), p.845-847
Main Authors: Bi, Xiaolin, Gong, Min, Srikanta, Deepa, Rong, Yikang S
Format: Article
Language:English
Subjects:
Animals
Cell Cycle Proteins - genetics
Dose-Response Relationship, Radiation
Drosophila - genetics
Drosophila Proteins - genetics
Endodeoxyribonucleases - genetics
Genes, cdc
Mitosis - genetics
Mitosis - radiation effects
Models, Genetic
Mutagenesis
Protein-Serine-Threonine Kinases - genetics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Others have suggested recently that the conserved ATM checkpoint kinase is minimally involved in controlling the G(2)/M checkpoint in Drosophila that serves to prevent mitotic entry in the presence of DNA damage. Our data indicate that both ATM and its regulator Mre11 are important for the checkpoint and that their roles become essential when animals are challenged with a low dose of X rays or when they have compromised checkpoint function of the ATM-related ATR kinase.
ISSN:0016-6731
1943-2631
1943-2631
DOI:10.1534/genetics.105.047720