Drosophila ATM and Mre11 are essential for the G2/M checkpoint induced by low-dose irradiation

Others have suggested recently that the conserved ATM checkpoint kinase is minimally involved in controlling the G(2)/M checkpoint in Drosophila that serves to prevent mitotic entry in the presence of DNA damage. Our data indicate that both ATM and its regulator Mre11 are important for the checkpoin...

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Published in:Genetics (Austin) 2005-10, Vol.171 (2), p.845-847
Main Authors: Bi, Xiaolin, Gong, Min, Srikanta, Deepa, Rong, Yikang S
Format: Article
Language:English
Subjects:
Animals
Cell Cycle Proteins - genetics
Dose-Response Relationship, Radiation
Drosophila - genetics
Drosophila Proteins - genetics
Endodeoxyribonucleases - genetics
Genes, cdc
Mitosis - genetics
Mitosis - radiation effects
Models, Genetic
Mutagenesis
Protein-Serine-Threonine Kinases - genetics
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cited_by cdi_FETCH-LOGICAL-c3840-e297a8b5cdb56f1f268984e1ccbc71168cb787ce7f4c13fcc3be028751b38e5e3
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Srikanta, Deepa
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description Others have suggested recently that the conserved ATM checkpoint kinase is minimally involved in controlling the G(2)/M checkpoint in Drosophila that serves to prevent mitotic entry in the presence of DNA damage. Our data indicate that both ATM and its regulator Mre11 are important for the checkpoint and that their roles become essential when animals are challenged with a low dose of X rays or when they have compromised checkpoint function of the ATM-related ATR kinase.
doi_str_mv 10.1534/genetics.105.047720
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source Freely Accessible Science Journals; Oxford Journals Online; Alma/SFX Local Collection
subjects Animals
Cell Cycle Proteins - genetics
Dose-Response Relationship, Radiation
Drosophila - genetics
Drosophila Proteins - genetics
Endodeoxyribonucleases - genetics
Genes, cdc
Mitosis - genetics
Mitosis - radiation effects
Models, Genetic
Mutagenesis
Protein-Serine-Threonine Kinases - genetics
title Drosophila ATM and Mre11 are essential for the G2/M checkpoint induced by low-dose irradiation
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