effect of dietary amino acids on immune reactivity

The plaque-forming cell response and serum antibody titres to sheep red blood cells (SRBC) were enhanced in mice fed diets moderately deficient in the amino acids phenylalanine-tyrosine. These diets sustained normal growth during a 4 week study period. More severe limitation of phenylalanine-tyrosin...

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Bibliographic Details
Published in:Immunology 1978-08, Vol.35 (2), p.257-266
Main Authors: Bounous, G, Kongshavn, P.A.L
Format: Article
Language:English
Subjects:
Amino Acids - deficiency
Amino Acids, Essential - deficiency
Animals
Antibodies - analysis
Antibody Formation
Diet
Hemolytic Plaque Technique
human nutrition
Hypersensitivity, Delayed
Immunity, Cellular
Male
Mice
Mice, Inbred Strains
nutrition education
Organ Size
Phenylalanine - deficiency
Spleen - anatomy & histology
Tyrosine - deficiency
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Summary:The plaque-forming cell response and serum antibody titres to sheep red blood cells (SRBC) were enhanced in mice fed diets moderately deficient in the amino acids phenylalanine-tyrosine. These diets sustained normal growth during a 4 week study period. More severe limitation of phenylalanine-tyrosine or multiple essential amino acid restriction gave rise to a slight increas in the delayed hypersensitivity reaction to SRBC. These latter diets usually limit growth; nevertheless the humoral immune response to SRBC was not significantly depressed except in the mice fed a diet (diet 7) with severe restriction of seven essential amino acids. These results suggest that dietary restriction may suppress the production or function of an inhibitory cell, such as a suppressor T cell, whilst not affecting the effector cell to the same degree.
ISSN:0019-2805
1365-2567