Arabidopsis homolog of trithorax, ATX1, binds phosphatidylinositol 5-phosphate, and the two regulate a common set of target genes

The Arabidopsis homolog of trithorax, ATX1, regulates numerous functions in Arabidopsis beyond the homeotic genes. Here, we identified genome-wide targets of ATX1 and showed that ATX1 is a receptor for a lipid messenger, phosphatidylinositol 5-phosphate, PI5P. PI5P negatively affects ATX1 activity,...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2006-04, Vol.103 (15), p.6049-6054
Main Authors: Alvarez-Venegas, R, Sadder, M, Hlavacka, A, Baluska, F, Xia, Y, Lu, G, Firsov, A, Sarath, G, Moriyama, H, Dubrovsky, J.G
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Arabidopsis
Arabidopsis - genetics
Arabidopsis - metabolism
Arabidopsis Proteins - genetics
Arabidopsis Proteins - metabolism
Arabidopsis thaliana
binding capacity
binding proteins
Biological Sciences
Botany
Cell nucleus
cytochemistry
Epidermal cells
Gene expression
Gene expression regulation
Gene Expression Regulation, Plant
Genes
histochemistry
Histone-Lysine N-Methyltransferase
Histones
Ligands
Lipids
Models, Molecular
Molecular Sequence Data
phosphatidylinositol 5-phosphate
Phosphatidylinositol Phosphates - metabolism
Phosphatidylinositols
Plants
Protein Conformation
Receptors
regulatory proteins
signal transduction
transcription (genetics)
Transcription Factors - deficiency
Transcription Factors - genetics
Transcription Factors - metabolism
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Summary:The Arabidopsis homolog of trithorax, ATX1, regulates numerous functions in Arabidopsis beyond the homeotic genes. Here, we identified genome-wide targets of ATX1 and showed that ATX1 is a receptor for a lipid messenger, phosphatidylinositol 5-phosphate, PI5P. PI5P negatively affects ATX1 activity, suggesting a regulatory pathway connecting lipid-signaling with nuclear functions. We propose a model to illustrate how plants may respond to stimuli (external or internal) that elevate cellular PI5P levels by altering expression of ATX1-controlled genes.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.0600944103