Evaluating gene flow using selected markers: a case study

The extent to which an organism is locally adapted in an environmental pocket depends on the selection intensities inside and outside the pocket, on migration, and on the size of the pocket. When two or more loci are involved in this local adaptation, measuring their frequency gradients and their li...

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Bibliographic Details
Published in:Genetics (Austin) 1998-07, Vol.149 (3), p.1383-1392
Main Authors: Lenormand, T. (Universite Montpellier II, Montpellier, France.), Guillemaud, T, Bourguet, D, Raymond, M
Format: Article
Language:English
Subjects:
ACETILCOLINESTERASA
ACETYLCHOLINESTERASE
ADAPTACION
ADAPTATION
ALLELES
Animals
COMPOSE ORGANOPHOSPHORE
COMPUESTO ORGANICO DEL FOSFORO
Computer Simulation
Culex - genetics
CULEX PIPIENS
CULEX PIPIENS PIPIENS
DOMINANCE
ESTERASAS
ESTERASE
ESTERASES
ESTIMATION
Female
FRANCE
FRANCIA
GENE
GENE FREQUENCY
GENES
Genetic Markers
Genetic Variation
Genetics
Genotype
INSECTICIDAS
INSECTICIDE
Insecticide Resistance - genetics
INSECTICIDES
Life Sciences
LINKAGE DISEQUILIBRIUM
LOCI
LOCUS
Male
MAXIMUM LIKELIHOOD
METHODE STATISTIQUE
METODOS ESTADISTICOS
MIGRACION
MIGRATION
Models, Genetic
Models, Statistical
NATURAL SELECTION
ORGANOPHOSPHORUS COMPOUNDS
Phenotype
RECOMBINACION
RECOMBINAISON
RECOMBINATION
RESISTANCE AUX PRODUITS CHIMIQUES
RESISTANCE TO CHEMICALS
RESISTENCIA A PRODUCTOS QUIMICOS
SELECCION
SELECCION NATURAL
SELECTION
SELECTION NATURELLE
SELECTION PRESSURE
STATISTICAL METHODS
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Summary:The extent to which an organism is locally adapted in an environmental pocket depends on the selection intensities inside and outside the pocket, on migration, and on the size of the pocket. When two or more loci are involved in this local adaptation, measuring their frequency gradients and their linkage disequilbria allows one to disentangle the forces-migration and selection-acting on the system. We apply this method to the case of a local adaptation to organophosphate insecticides in the mosquito Culex pipiens pipiens in southern France. The study of two different resistance loci allowed us to estimate with support limits gene flow as well as selection pressure on insecticide resistance and the fitness costs associated with each locus. These estimates permit us to pinpoint the conditions for the maintenance of this pocket of adaptation as well as the effect of the interaction between the two resistance loci.
ISSN:0016-6731
1943-2631
1943-2631
DOI:10.1093/genetics/149.3.1383