RNase E Processing of Essential Cell Division Genes mRNA in Escherichia Coli

The ratio of the FtsZ to FtsA proteins determines the correct initiation of cell division in Escherichia coli. The genes for these proteins are contiguous on the chromosome. Although both genes are transcribed from common promoters, the presence of ftsZ-specific promoters, along with differences in...

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Bibliographic Details
Published in:Nucleic acids research 1996-08, Vol.24 (15), p.3065-3070
Main Authors: Cam, Kaymeuang, Rome, Gilles, Krisch, Henry M., Bouché, Jean-Pierre
Format: Article
Language:English
Subjects:
Bacterial Proteins - biosynthesis
Bacterial Proteins - genetics
Base Sequence
Cell Division - genetics
Cytoskeletal Proteins
Endoribonucleases - metabolism
Escherichia coli
Escherichia coli - cytology
Escherichia coli - genetics
Escherichia coli Proteins
Gene Expression Regulation, Bacterial
Molecular Sequence Data
RNA Processing, Post-Transcriptional
RNA, Bacterial - metabolism
RNA, Messenger - metabolism
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Summary:The ratio of the FtsZ to FtsA proteins determines the correct initiation of cell division in Escherichia coli. The genes for these proteins are contiguous on the chromosome. Although both genes are transcribed from common promoters, the presence of ftsZ-specific promoters, along with differences in the efficiency of translation of their respective mRNAs, contribute to the increased relative expression of ftsZ. We report here that the polycistronic ftsA-ftsZ transcripts are cleaved by RNase E and that this cleavage affects the decay of ftsA and ftsZ mRNA. As a consequence of the cleavage, RNase E also contributes to the differential expression of the two genes.
ISSN:0305-1048
1362-4962
1362-4962
DOI:10.1093/nar/24.15.3065