Genetic characterization of the Drosophila melanogaster suppressor of deltex gene: a regulator of notch signaling

The Notch receptor signaling pathway regulates cell differentiation during the development of multicellular organisms. A number of genes are known to be components of the pathway or regulators of the Notch signal. One candidate for a modifier of Notch function is the Drosophila Suppressor of deltex...

Full description

Saved in:
Bibliographic Details
Published in:Genetics (Austin) 1998-12, Vol.150 (4), p.1477-1485
Main Authors: Fostier, M. (University of Manchester, UK.), Evans, D.A.P, Artavanis-Tsakonas, S, Baron, M
Format: Article
Language:English
Subjects:
AILE
ALAS
ALLELES
Animals
BINDING PROTEINS
BIOLOGICAL DEVELOPMENT
BLOOD VEINS
CARTE GENETIQUE
CHROMOSOME
Chromosome Mapping
CHROMOSOMES
CROMOSOMAS
DESARROLLO BIOLOGICO
DEVELOPPEMENT BIOLOGIQUE
DROSOPHILA MELANOGASTER
Drosophila melanogaster - genetics
Drosophila Proteins
FENOTIPOS
GENE
GENE INTERACTION
GENES
Genes, Insect
Genes, Suppressor - genetics
Genes, Suppressor - physiology
GENETIC MAPS
Genetics
Insect Proteins - genetics
Insect Proteins - physiology
INTERACCION DE GENES
INTERACTION GENIQUE
MAPAS GENETICOS
Membrane Proteins - metabolism
MODIFIERS
MUTACION
MUTATION
PHENOTYPE
PHENOTYPES
POLYTENE CHROMOSOMES
PROTEINAS
PROTEINAS AGLUTINANTES
PROTEINE
PROTEINE DE LIAISON
PROTEINS
Receptors, Notch
REGULATION
Signal Transduction
SU(DX) GENE
SURFACE PROTEINS
VEINE
VENAS
WINGS
Wings, Animal
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The Notch receptor signaling pathway regulates cell differentiation during the development of multicellular organisms. A number of genes are known to be components of the pathway or regulators of the Notch signal. One candidate for a modifier of Notch function is the Drosophila Suppressor of deltex gene [Su(dx)]. We have isolated four new alleles of Su(dx) and mapped the gene between 22B4 and 22C2. Loss-of-function Su(dx) mutations were found to suppress phenotypes resulting from loss-of-function of Notch signaling and to enhance gain-of-function Notch mutations. Hairless, a mutation in a known negative regulator of the Notch pathway, was also enhanced by Su(dx). Phenotypes were identified for Su(dx) in wing vein development, and a role was demonstrated for the gene between 20 and 30 hr after puparium formation. This corresponds to the period when the Notch protein is involved in refining the vein competent territories. Taken together, our data indicate a role for Su(dx) as a negative regulator of Notch function.
ISSN:0016-6731
1943-2631
1943-2631
DOI:10.1093/genetics/150.4.1477