structure and paramutagenicity of the R-marbled haplotype of Zea mays

Paramutation is the meiotically heritable silencing of a gene that can occur in particular heterozygous combinations. The R-marbled (R-mb) haplotype is paramutagenic: it causes paramutable r1 haplotypes like R-r to become heritably silenced. R-mb was found to comprise three distinct r1 genes arrange...

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Bibliographic Details
Published in:Genetics (Austin) 1999-10, Vol.153 (2), p.979-991
Main Authors: Panavas, T, Weir, J, Walker, E.L
Format: Article
Language:English
Subjects:
aleurone layer
anthocyanins
Base Sequence
chromosome mapping
Crosses, Genetic
crossing over
DNA Primers
DNA Transposable Elements
genbank/af135456
genbank/af135457
genbank/af135458
genbank/af136220
genbank/af136221
gene copy number
gene dosage
Genes, Plant
Haplotypes
Heterozygote
lcm1 gene
lcm2 gene
Meiosis
Molecular Sequence Data
multiple genes
Mutagenesis
mutagenicity
mutation
nucleotide sequences
paramutations
pigmentation
Polymerase Chain Reaction
r1 gene
Recombination, Genetic
regulator genes
Restriction Mapping
transcription factors
transposons
variegation
Zea mays
Zea mays - genetics
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Summary:Paramutation is the meiotically heritable silencing of a gene that can occur in particular heterozygous combinations. The R-marbled (R-mb) haplotype is paramutagenic: it causes paramutable r1 haplotypes like R-r to become heritably silenced. R-mb was found to comprise three distinct r1 genes arranged as direct repeats. The most distal gene of R-mb, Scm, contains a novel transposable element, Shooter (Sho). Excision of the Sho element early in aleurone development results in the characteristic "marbled" aleurone pigmentation pattern conferred by R-mb. The effect of gene copy number on the paramutagenic strength of R-mb was tested. Paramutagenic strength of R-mb is directly correlated with r1 gene copy number. Paramutagenic strength of R-mb is directly correlated with r1 gene copy number. Paramutagenic strength of R-mb was not affected by removal, through crossing over, of the Sho transposon. Finally, R-mb does not appear to contain the transposable element, Doppia, which is associated with paramutability of R-r, and has been suggested to play a role in paramutagenicity of another paramutagenic haplotype, R-stippled.
ISSN:0016-6731
1943-2631
1943-2631
DOI:10.1093/genetics/153.2.979