SIR2-Induced Inviability Is Suppressed by Histone H4 Overexpression

We have identified histone H4 as a high-expression suppressor of Sir2-induced inviability in yeast cells. Overexpression of histone H3 does not suppress Sir2-induced lethality, nor does overexpression of histone H4 alleles associated with silencing defects. These results suggest a direct and specifi...

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Bibliographic Details
Published in:Genetics (Austin) 2002-10, Vol.162 (2), p.973-976
Main Authors: Matecic, Mirela, Stuart, Shelagh, Holmes, Scott G
Format: Article
Language:English
Subjects:
Cellular biology
Deoxyribonucleic acid
DNA
Genes, Lethal
Histone Deacetylases - genetics
Histone Deacetylases - metabolism
Histones - genetics
Histones - metabolism
Lysine - metabolism
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae - metabolism
Silent Information Regulator Proteins, Saccharomyces cerevisiae - genetics
Silent Information Regulator Proteins, Saccharomyces cerevisiae - metabolism
Sirtuin 2
Sirtuins - genetics
Sirtuins - metabolism
Suppression, Genetic
Yeast
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Summary:We have identified histone H4 as a high-expression suppressor of Sir2-induced inviability in yeast cells. Overexpression of histone H3 does not suppress Sir2-induced lethality, nor does overexpression of histone H4 alleles associated with silencing defects. These results suggest a direct and specific interaction between Sir2 and H4 in the silencing mechanism.
ISSN:0016-6731
1943-2631
1943-2631
DOI:10.1093/genetics/162.2.973