The α/β fold family of proteins database and the cholinesterase gene server ESTHER

ESTHER (for esterases, α/β hydrolase enzyme and relatives) is a database of sequences phylogenetically related to cholinesterases. These sequences define a homogeneous group of enzymes (carboxylesterases, lipases and hormone-sensitive lipases) sharing a similar structure of a central β-sheet surroun...

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Bibliographic Details
Published in:Nucleic acids research 1997-01, Vol.25 (1), p.143-146
Main Authors: Cousin, Xavier, Hotelier, Thierry, Giles, Kurt, Lievin, Philippe, Toutant, Jean-Pierre, Chatonnet, Arnaud
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Base Sequence
Cholinesterases - genetics
Computer Science
Databases, Factual
Genes - genetics
Humans
Life Sciences
Lipase - genetics
Molecular Sequence Data
Software
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Summary:ESTHER (for esterases, α/β hydrolase enzyme and relatives) is a database of sequences phylogenetically related to cholinesterases. These sequences define a homogeneous group of enzymes (carboxylesterases, lipases and hormone-sensitive lipases) sharing a similar structure of a central β-sheet surrounded by α-helices. Among these proteins a wide range of functions can be found (hydrolases, adhesion molecules, hormone precursors). The purpose of ESTHER is to help comparison of structures and functions of members of the family. Since the last release, new features have been added to the server. A BLAST comparison tool allows sequence homology searches within the database sequences. New sections are available: kinetics and inhibitors of cholinesterases, fasciculin-acetylcholinesterase interaction and a gene structure review. The mutation analysis compilation has been improved with three-dimensional images. A mailing list has been created.
ISSN:0305-1048
1362-4962
DOI:10.1093/nar/25.1.143