Pathways of interstitial fluid and lymph flow in the liver acinus of the sheep and mouse

In the acinus of the sheep and mouse liver, lymphatic vessels are restricted to the portal tracts. Vessels less than about 25 μm across form a network around portal venules, and are closely associated with the limiting plate of hepatocytes. The perisinusoidal space of Disse is continuous with the in...

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Bibliographic Details
Published in:American journal of anatomy 1998-04, Vol.192 (3), p.351-358
Main Authors: HEATH, TREVOR, LOWDEN, STEWART
Format: Article
Language:English
Subjects:
Animals
Extracellular Space
Image Processing, Computer-Assisted
Liver - anatomy & histology
Liver - immunology
Liver - ultrastructure
Lymphatic System - anatomy & histology
Lymphatic System - ultrastructure
Mice
Microscopy, Electron
Portal tracts
Sheep - anatomy & histology
space of Disse
space of Mall
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Summary:In the acinus of the sheep and mouse liver, lymphatic vessels are restricted to the portal tracts. Vessels less than about 25 μm across form a network around portal venules, and are closely associated with the limiting plate of hepatocytes. The perisinusoidal space of Disse is continuous with the interstitial space of the portal tracts at the origin of the sinusoids. It seems likely that excess interstitial fluid derived from the sinusoids flows along the perisinusoidal space of Disse to enter the portal tracts near the portal venules, and then enters the small lymphatics which lie adjacent to those venules. It then enters the larger vessels, which are adjacent to hepatic arterioles and bile ductules.
ISSN:0002-9106
0021-8782
1553-0795
1469-7580
DOI:10.1046/j.1469-7580.1998.19230351.x