Forkhead transcription factors are targets of signalling by the proto-oncogene PKB (C-AKT)

Following the discovery that the proto-oncogene protein kinase B (PKB) functions as a downstream element in signalling from phosphoinositide 3′-kinase (PI3-kinase) (Burgering & Coffer, 1995), PKB has been shown to mediate a diverse array of PI3-kinase dependent cellular responses. Most recently...

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Bibliographic Details
Published in:American journal of anatomy 2000-11, Vol.197 (4), p.571-574
Main Authors: KOPS, G. J. P. L., BURGERING, B. M. T.
Format: Article
Language:English
Subjects:
Animals
c‐akt
Forkhead Transcription Factors
Humans
Mammals - physiology
Minireview
Nuclear Proteins - metabolism
Phosphatidylinositol 3-Kinases - metabolism
Phosphorylation
Protein kinase B
Protein-Serine-Threonine Kinases
Proto-Oncogene Proteins - metabolism
Proto-Oncogene Proteins c-akt
Signal Transduction - physiology
Transcription Factors - metabolism
Transcription, Genetic - physiology
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Summary:Following the discovery that the proto-oncogene protein kinase B (PKB) functions as a downstream element in signalling from phosphoinositide 3′-kinase (PI3-kinase) (Burgering & Coffer, 1995), PKB has been shown to mediate a diverse array of PI3-kinase dependent cellular responses. Most recently PKB-dependent phosphorylation of 3 members of the family of Forkhead transcription factors has been demonstrated to play a role in PI3-kinase dependent effects on transcription. This review focuses on this newly discovered function of PKB in conveying the diversity of PI3-kinase dependent cellular responses.
ISSN:0002-9106
0021-8782
1553-0795
1469-7580
DOI:10.1046/j.1469-7580.2000.19740571.x