The Role of Vitamin D in Cancer Prevention

Vitamin D status differs by latitude and race, with residents of the northeastern United States and individuals with more skin pigmentation being at increased risk of deficiency. A PubMed database search yielded 63 observational studies of vitamin D status in relation to cancer risk, including 30 of...

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Bibliographic Details
Published in:American journal of public health (1971) 2006-02, Vol.96 (2), p.252-261
Main Authors: Garland, Cedric F, Garland, Frank C, Gorham, Edward D, Lipkin, Martin, Newmark, Harold, Mohr, Sharif B, Holick, Michael F
Format: Article
Language:English
Subjects:
Anniversaries
Biological and medical sciences
Breast cancer
Breast Neoplasms - epidemiology
Colorectal cancer
Colorectal Neoplasms - epidemiology
Continental Population Groups - statistics & numerical data
Dealing with Innovation and Uncertainty
Exercise
Female
Humans
Male
Medical sciences
Metabolites
Miscellaneous
Mortality
Neoplasms - epidemiology
Neoplasms - prevention & control
Nutrition
Observational studies
Ovarian cancer
Preventive medicine
Prostate cancer
Prostatic Neoplasms - epidemiology
Public health
Public health. Hygiene
Public health. Hygiene-occupational medicine
Radiation
Risk
Tumors
Ultraviolet radiation
United States - epidemiology
Vitamin D
Vitamin D - administration & dosage
Vitamin D - blood
Vitamin D - therapeutic use
Vitamin D Deficiency - blood
Vitamin D Deficiency - epidemiology
Vitamin deficiency
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Description
Summary:Vitamin D status differs by latitude and race, with residents of the northeastern United States and individuals with more skin pigmentation being at increased risk of deficiency. A PubMed database search yielded 63 observational studies of vitamin D status in relation to cancer risk, including 30 of colon, 13 of breast, 26 of prostate, and 7 of ovarian cancer, and several that assessed the association of vitamin D receptor genotype with cancer risk. The majority of studies found a protective relationship between sufficient vitamin D status and lower risk of cancer. The evidence suggests that efforts to improve vitamin D status, for example by vitamin D supplementation, could reduce cancer incidence and mortality at low cost, with few or no adverse effects.
ISSN:0090-0036
1541-0048
DOI:10.2105/AJPH.2004.045260