Simulations of conduction in uniform myelinated fibers. Relative sensitivity to changes in nodal and internodal parameters

Conduction of impulses in myelinated axons has been studied by a new method of computer simulation. The contributions of nodal and internodal characteristics and parameters were examined. Surprisingly, the conduction velocity, theta, was found to be quite insensitive to the nodal area or the exact d...

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Bibliographic Details
Published in:Biophysical journal 1978-02, Vol.21 (2), p.147-160
Main Authors: Moore, J.W., Joyner, R.W., Brill, M.H., Waxman, S.D., Najar-Joa, M.
Format: Article
Language:English
Subjects:
Axons - physiology
Computers
Electric Conductivity
Kinetics
Models, Neurological
Myelin Sheath - physiology
Nerve Fibers, Myelinated - physiology
Neural Conduction
Ranvier's Nodes - physiology
Temperature
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Summary:Conduction of impulses in myelinated axons has been studied by a new method of computer simulation. The contributions of nodal and internodal characteristics and parameters were examined. Surprisingly, the conduction velocity, theta, was found to be quite insensitive to the nodal area or the exact description of its excitable processes. The conduction velocity also is relatively insensitive to the internodal length but much more sensitive to the myelin capacitance and axoplasm conductance. Qualitative change in theta with temperature depended on which temperature-sensitive parameters were included in the simulation.
ISSN:0006-3495
1542-0086
DOI:10.1016/S0006-3495(78)85515-5