No Evidence for Association with Parkinson Disease for 13 Single-Nucleotide Polymorphisms Identified by Whole-Genome Association Screening

Fewer than half of the SNPs (46%) showed allele frequency differences between cases and controls in the same direction as that reported by Maraganore et al.1 The combination of our data with those from the original report, with the use of the Mantel-Haenszel test statistic (Statsdirect) and correcti...

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Bibliographic Details
Published in:American journal of human genetics 2006-06, Vol.78 (6), p.1088-1090
Main Authors: Goris, A., Williams-Gray, C.H., Foltynie, T., Compston, D.A.S., Barker, R.A., Sawcer, S.J.
Format: Article
Language:English
Subjects:
Adult
Age of Onset
Aged
Aged, 80 and over
Female
Genetic Predisposition to Disease
Genetic testing
Genetics
Genome, Human - genetics
Humans
Letter to the Editor
Male
Middle Aged
Parkinson Disease - genetics
Parkinsons disease
Polymorphism
Polymorphism, Single Nucleotide
Sequence Analysis, DNA
Studies
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Description
Summary:Fewer than half of the SNPs (46%) showed allele frequency differences between cases and controls in the same direction as that reported by Maraganore et al.1 The combination of our data with those from the original report, with the use of the Mantel-Haenszel test statistic (Statsdirect) and correction for the 11 independent tests performed, revealed that only three markers (rs10200894, ss46548856, and rs7702187) retain any evidence of significance at the 5% level in the total data (table 1).
ISSN:0002-9297
1537-6605
DOI:10.1086/504726