Urine mutagenicity as an indicator of exposure to dietary mutagens formed during cooking of foods

Studies were undertaken with individuals fed fried bacon meals to determine whether fruit or vegetables, ingested along with bacon, modified uptake and subsequent excretion of bacon mutagen(s). Urinary mutagenic activity was significant in those who had consumed bacon or mixed bacon/vegetable or bac...

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Bibliographic Details
Published in:Environmental health perspectives 1986-08, Vol.67, p.147-152
Main Authors: Baker, R.S.U, Darnton-Hill, I, Bonin, A.M, Arlauskas, A, Braithwaite, C, Wootton, M, Truswell, A.S
Format: Article
Language:English
Subjects:
1984 International Chemical Congress of Pacific Basin Societies. Formation of Mutagens during Cooking and Heat Processing of Food. December 16-21, 1984. Honolulu, Hawaii
Animals
Chemical hazards
Cigarette smoking
COCCION
COOKING
Creatinine - urine
CUISSON
DIET
Diet - adverse effects
DIETA
Excretion
Female
Food
Food Contamination
FOOD TECHNOLOGY
Fruit
Fruits
Hot Temperature
Humans
Male
Meat - adverse effects
Meats
MUTAGENE
Mutagenicity
MUTAGENOS
MUTAGENS
Mutagens - metabolism
ORINA
REGIME ALIMENTAIRE
Swine
TECHNOLOGIE ALIMENTAIRE
TECNOLOGIA DE LOS ALIMENTOS
URINE
Vegetables
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Description
Summary:Studies were undertaken with individuals fed fried bacon meals to determine whether fruit or vegetables, ingested along with bacon, modified uptake and subsequent excretion of bacon mutagen(s). Urinary mutagenic activity was significant in those who had consumed bacon or mixed bacon/vegetable or bacon/fruit meals within the previous 2 to 3 hr period. Although urine activity varied by a factor of 4 among 15 subjects who consumed different meals, there was no evidence from this investigation that fruit or vegetables contributed to the inherent variability in total urinary mutagenic activity. However, some differences in excretion kinetics may be attributable to vegetable or fruit supplements in mixed meals.
ISSN:0091-6765
1552-9924
DOI:10.1289/ehp.8667147