Concentration-Time Relationship for Various Regimens of Inhalation of Organic Compounds

An attempt was made to establish a concentration-time relationship for continuous and interrupted inhalation of a number of nonelectrolytes to establish norms for the permissible content of harmful substances in atmospheric air. The tests showed that the indicated relationship can be expressed in th...

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Bibliographic Details
Published in:Environmental health perspectives 1976-02, Vol.13, p.17-21
Main Authors: Sidorenko, G. I., Pinigin, M. A.
Format: Article
Language:English
Subjects:
Acute toxicity
Aerosols - toxicity
Alcohols
Aniline Compounds - toxicity
Animals
Benzene Derivatives - toxicity
Biochemistry
Carbon
Chemical hazards
Hydrocarbons - toxicity
Inhalation
Lethal Dose 50
Mice
Rats
Solubility
Time dependence
Time Factors
Toxicology
Toxins
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Summary:An attempt was made to establish a concentration-time relationship for continuous and interrupted inhalation of a number of nonelectrolytes to establish norms for the permissible content of harmful substances in atmospheric air. The tests showed that the indicated relationship can be expressed in the form of a straight line on a logarithmic grid by using either acute toxicity parameters or the onset of physiological and biochemical shifts. This makes it possible to predict the chronic effect thresholds of substances on the basis of the results of short-term experiments.
ISSN:0091-6765
DOI:10.2307/3428231