Pulmonary Response to Polyurethane Dust

Weanling and 9 months or older rats were exposed to particles of an aged (PUF I) or freshly prepared (PUF II) rigid polyurethane foam by intratracheal intubation. The dose was 5 mg of particles. The response of the lung tissue was examined morphologically by serial sacrifices. Inflammation and macro...

Full description

Saved in:
Bibliographic Details
Published in:Environmental health perspectives 1975-06, Vol.11, p.109-113
Main Authors: Stemmer, Klaus L., Bingham, Eula, Barkley, William
Format: Article
Language:English
Subjects:
Age Factors
Animals
Bronchial Neoplasms - chemically induced
Cystadenoma - chemically induced
Dust
Emphysema
Environmental Exposure
Female
Fibrosis
Foams
Inhalation
Intubation
Intubation, Intratracheal
Lesions
Lung - ultrastructure
Lung Diseases - chemically induced
Lung Neoplasms - chemically induced
Lungs
Lymphocytes - drug effects
Macrophages
Macrophages - drug effects
Male
Neoplasia
Particle Size
Polyurethanes - administration & dosage
Polyurethanes - toxicity
Proceedings of the NIEHS Conference on Public Health Implications of Components of Plastics Manufacture, Pinehurst, North Carolina, July 29-31, 1974
Pulmonary Emphysema - chemically induced
Pulmonary Fibrosis - chemically induced
Rats
Scars
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Weanling and 9 months or older rats were exposed to particles of an aged (PUF I) or freshly prepared (PUF II) rigid polyurethane foam by intratracheal intubation. The dose was 5 mg of particles. The response of the lung tissue was examined morphologically by serial sacrifices. Inflammation and macrophage activity were the initial responses. Fibrosis developed after 6 months. Nodular scars and perifocal emphysema were seen after 12 months. Four rats had a papillary adenoma in a major bronchus after 18 months exposure to PUF II.
ISSN:0091-6765
1552-9924
DOI:10.1289/ehp.7511109