Dose-Dependent Fate of Vinyl Chloride and Its Possible Relationship to Oncogenicity in Rats

Studies on the fate of14C-labeled vinyl chloride (VC) following oral administration and inhalation exposure in rats demonstrated that the disposition of VC in the body is a function of the dose. More importantly, from the data available, it appears that a correlation exists between doses of VC which...

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Bibliographic Details
Published in:Environmental health perspectives 1976-10, Vol.17, p.145-152
Main Authors: Watanabe, P. G., Gehring, P. J.
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Breath Tests
Carcinogens
Chemical hazards
Chlorides
Dosage
Dose-Response Relationship, Drug
Environmental health
Excretion
Liver - drug effects
Liver - metabolism
Metabolism
Metabolites
Proceedings of the WHO-NIEHS Conference on Potential Environmental Health Hazards from Technological Developments in Rubber and Plastics Industries. Research Triangle Park, N.C., March 1-3, 1976
Rats
Sulfhydryl Compounds - metabolism
Time Factors
Tumors
Urine
Vinyl Chloride - administration & dosage
Vinyl Chloride - metabolism
Vinyl Chloride - pharmacology
Vinyl Compounds - metabolism
Vital capacity
Volatilization
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Summary:Studies on the fate of14C-labeled vinyl chloride (VC) following oral administration and inhalation exposure in rats demonstrated that the disposition of VC in the body is a function of the dose. More importantly, from the data available, it appears that a correlation exists between doses of VC which cause tumors and those that saturate metabolic or detoxifying pathways. Additional studies characterized the depression of liver non-protein sulfhydryl content (primarily GSH) with the duration and concentration of exposure to VC. The results of these investigations indicate that statistical projections utilizing data collected from rats exposed to high doses of VC are invalid for predicting the hazard of low level exposure, because such projections violate the a priori assumption that the dynamics governing the fate of VC in the body are unaltered.
ISSN:0091-6765
1552-9924
DOI:10.1289/ehp.7617145