Characterization of acute interstitial pneumonia in cattle in southern Alberta feedyards

Field data were collected over 2 consecutive years to characterize acute interstitial pneumonia (AIP) in feedyard cattle. Thirty-eight cattle with clinical symptoms of AIP were examined following emergency slaughter; 31 (all heifers) were confirmed to have AIP on the basis of gross and histological...

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Bibliographic Details
Published in:Canadian veterinary journal 2000-07, Vol.41 (7), p.547-554
Main Authors: Ayroud, M, Popp, J D, VanderKop, M A, Yost, G S, Haines, D M, Majak, W, Karren, D, Yanke, L J, McAllister, T A
Format: Article
Language:English
Subjects:
Acute Disease
Animal Feed
Animal Husbandry
Animals
Cattle
Cattle Diseases - microbiology
Cattle Diseases - pathology
Lung Diseases, Interstitial - microbiology
Lung Diseases, Interstitial - pathology
Lung Diseases, Interstitial - veterinary
Pneumonia - microbiology
Pneumonia - pathology
Pneumonia - veterinary
Skatole - blood
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Summary:Field data were collected over 2 consecutive years to characterize acute interstitial pneumonia (AIP) in feedyard cattle. Thirty-eight cattle with clinical symptoms of AIP were examined following emergency slaughter; 31 (all heifers) were confirmed to have AIP on the basis of gross and histological lung pathology. The 7 without AIP, plus 17 asymptomatic penmates, were used as contemporary controls. Plasma concentrations of 3-methylindole (3MI) metabolites were higher (P < 0.001) in heifers afflicted with AIP than in the control animals, and concentrations of 3MI mercapturates in the urine were lower (P < 0.007) in affected heifers. Concentrations of 3MI adducts in lung tissue and in microsomal protein did not differ (P > 0.05) between the 2 groups, and 3MI was not detected in ruminal fluid from either group. Total ruminal bacterial numbers and populations of lactobacilli and protozoa were similar (P > 0.05) between the AIP-positive and unafflicted groups, but fewer (P < 0.05) cellulolytic bacteria were present in the positive group. Bovine respiratory syncytial virus antigen was not found in lung tissue from any of the heifers confirmed to have AIP. To our knowledge, this study is the first to implicate 3MI metabolites as having a role in feedyard AIP. Further research is required to determine the factors responsible for the elevation in 3MI adducts in plasma and urine of feedyard cattle afflicted with AIP.
ISSN:0008-5286