Yeast Gal4: a transcriptional paradigm revisited

During the past two decades, the yeast Gal4 protein has been used as a model for studying transcriptional activation in eukaryotes. Many of the properties of transcriptional regulation first demonstrated for Gal4 have since been shown to be reiterated in the function of several other eukaryotic tran...

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Published in:EMBO reports 2006-05, Vol.7 (5), p.496-499
Main Authors: Traven, Ana, Jelicic, Branka, Sopta, Mary
Format: Article
Language:English
Subjects:
Cellular biology
DNA-Binding Proteins - biosynthesis
DNA-Binding Proteins - genetics
DNA-Binding Proteins - metabolism
DNA-Binding Proteins - physiology
Gal4
Gene Expression Regulation, Fungal - physiology
Models, Molecular
Proteins
Review
RNA polymerase II
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae - physiology
Saccharomyces cerevisiae Proteins - biosynthesis
Saccharomyces cerevisiae Proteins - genetics
Saccharomyces cerevisiae Proteins - metabolism
Saccharomyces cerevisiae Proteins - physiology
transcription
Transcription Factors - biosynthesis
Transcription Factors - genetics
Transcription Factors - metabolism
Transcription Factors - physiology
Transcription, Genetic - physiology
Transcriptional Activation - physiology
yeast
Yeasts
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creator Traven, Ana
Jelicic, Branka
Sopta, Mary
description During the past two decades, the yeast Gal4 protein has been used as a model for studying transcriptional activation in eukaryotes. Many of the properties of transcriptional regulation first demonstrated for Gal4 have since been shown to be reiterated in the function of several other eukaryotic transcriptional regulators. Technological advances based on the transcriptional properties of this factor—such as the two‐hybrid technology and Gal4‐inducible systems for controlled gene expression—have had far‐reaching influences in fields beyond transcription. In this review, we provide an updated account of Gal4 function, including data from new technologies that have been recently applied to the study of the GAL network.
doi_str_mv 10.1038/sj.embor.7400679
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subjects Cellular biology
DNA-Binding Proteins - biosynthesis
DNA-Binding Proteins - genetics
DNA-Binding Proteins - metabolism
DNA-Binding Proteins - physiology
Gal4
Gene Expression Regulation, Fungal - physiology
Models, Molecular
Proteins
Review
RNA polymerase II
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae - physiology
Saccharomyces cerevisiae Proteins - biosynthesis
Saccharomyces cerevisiae Proteins - genetics
Saccharomyces cerevisiae Proteins - metabolism
Saccharomyces cerevisiae Proteins - physiology
transcription
Transcription Factors - biosynthesis
Transcription Factors - genetics
Transcription Factors - metabolism
Transcription Factors - physiology
Transcription, Genetic - physiology
Transcriptional Activation - physiology
yeast
Yeasts
title Yeast Gal4: a transcriptional paradigm revisited
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