Preparing for the first breath: prenatal maturation of respiratory neural control

By birth, the regulatory neural network responsible for respiratory control is capable of generating robust rhythm-driving ventilation that can adjust to homeostatic needs. The advent of in vitro models isolated from prenatal rodents has significantly advanced our understanding of these processes. I...

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Bibliographic Details
Published in:The Journal of physiology 2006-02, Vol.570 (3), p.437-444
Main Authors: Greer, John J., Funk, Gregory D., Ballanyi, Klaus
Format: Article
Language:English
Subjects:
Animals
diaphragm
Fetus - physiology
Motor Neurons - physiology
Phrenic Nerve - cytology
Phrenic Nerve - embryology
Phrenic Nerve - physiology
Respiratory Center - cytology
Respiratory Center - embryology
Respiratory Center - physiology
Respiratory Mechanics - physiology
Topical Review
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Summary:By birth, the regulatory neural network responsible for respiratory control is capable of generating robust rhythm-driving ventilation that can adjust to homeostatic needs. The advent of in vitro models isolated from prenatal rodents has significantly advanced our understanding of these processes. In this topical review, we examine the development of medullary respiratory rhythm-generating centres and phrenic motoneurone–diaphragm properties during the prenatal period.
ISSN:0022-3751
1469-7793
DOI:10.1113/jphysiol.2005.097238