The University of Minnesota Biocatalysis/Biodegradation Database: specialized metabolism for functional genomics

The University of Minnesota Biocatalysis/Biodegradation database (UM-BBD, http://www.labmed.umn.edu/umbbd/index.html) first became available on the web in 1995 to provide information on microbial biocatalytic reactions of, and biodegradation pathways for, organic chemical compounds, especially those...

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Bibliographic Details
Published in:Nucleic acids research 1999, Vol.27 (1), p.373-376
Main Authors: Ellis, Lynda B. M., Hershberger, C. Douglas, Wackett, Lawrence P.
Format: Article
Language:English
Subjects:
Bacteria - genetics
Bacteria - metabolism
Bacterial Proteins - metabolism
Biodegradation, Environmental
Biotechnology
Catalysis
Databases, Factual - trends
Environmental Pollution
Enzymes - chemistry
Enzymes - genetics
Enzymes - metabolism
Genes, Bacterial - genetics
Genes, Bacterial - physiology
Humans
Information Storage and Retrieval
Internet
Minnesota
Universities
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Summary:The University of Minnesota Biocatalysis/Biodegradation database (UM-BBD, http://www.labmed.umn.edu/umbbd/index.html) first became available on the web in 1995 to provide information on microbial biocatalytic reactions of, and biodegradation pathways for, organic chemical compounds, especially those produced by man. Its goal is to become a representative database of biodegradation, spanning the diversity of known microbial metabolic routes, organic functional groups, and environmental conditions under which biodegradation occurs. The database can be used to enhance understanding of basic biochemistry, biocatalysis leading to speciality chemical manufacture, and biodegradation of environmental pollutants. It is also a resource for functional genomics, since it contains information on enzymes and genes involved in specialized metabolism not found in intermediary metabolism databases, and thus can assist in assigning functions to genes homologous to such less common genes. With information on >400 reactions and compounds, it is poised to become a resource for prediction of microbial biodegradation pathways for compounds it does not contain, a process complementary to predicting the functions of new classes of microbial genes.
ISSN:0305-1048
1362-4962
DOI:10.1093/nar/27.1.373