Dissociation of Biological Catch-Bond by Periodic Perturbation

The analysis of the P-selectin/PSGL-1 catch-slip bond that is periodically driven by a detaching force predicts that in the frequency range on the order of 1 s −1 the bond lifetime undergoes significant changes with respect to both frequency and amplitude of the force. The result indicates how varia...

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Bibliographic Details
Published in:Biophysical journal 2006-07, Vol.91 (2), p.L19-L21
Main Authors: Pereverzev, Yuriy V., Prezhdo, Oleg V.
Format: Article
Language:English
Subjects:
Animals
Biophysical Letters
Biophysics
Cellular biology
Humans
Inflammatory diseases
Kinetics
Membrane Glycoproteins - metabolism
Models, Theoretical
P-Selectin - metabolism
Pathology
Protein Binding
Shear Strength
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Summary:The analysis of the P-selectin/PSGL-1 catch-slip bond that is periodically driven by a detaching force predicts that in the frequency range on the order of 1 s −1 the bond lifetime undergoes significant changes with respect to both frequency and amplitude of the force. The result indicates how variations in the heart rate could have a substantial effect on leukocyte and lymphoid cell transport and adhesion to endothelial cells and platelets during inflammatory processes.
ISSN:0006-3495
1542-0086
DOI:10.1529/biophysj.106.087288